Tropospheric Delay in the Neapolitan and Vesuvius Areas (Italy) by Means of a Dense GPS Array: A Contribution for Weather Forecasting and Climate Monitoring

Studying the spatiotemporal distribution and motion of water vapour (WV), the most variable greenhouse gas in the troposphere, is pivotal, not only for meteorology and climatology, but for geodesy, too. In fact, WV variability degrades, in an unpredictable way, almost all geodetic observation based on the propagation of electromagnetic signal through the atmosphere. We use data collected on a dense GPS network, designed for the purposes of monitoring the active Neapolitan (Italy) volcanoes, to retrieve the tropospheric delay parameters and precipitable water vapour (PWV). This study has two main targets: (a) the analysis of long datasets (11 years) to extract trends of climatological meaning for the region; (b) studying the main features of the time evolution of the PWV during heavy raining events to gain knowledge on the preparatory stages of highly impacting thunderstorms. For the latter target, both differential and precise point positioning (PPP) techniques are used, and the results are compared and critically discussed. An increasing trend, amounting to about 2 mm/decades, has been recognized in the PWV time series, which is in agreement with the results achieved in previous studies for the Mediterranean area. A clear topographic effect is detected for the Vesuvius volcano sector of the network and a linear relationship between PWV and altitude is quantitatively assessed. This signature must be taken into account in any modelling for the atmospheric correction of geodetic and remote-sensing data (e.g., InSAR). Characteristic temporal evolutions were recognized in the PWV in the targeted thunderstorms (which occurred in 2019 and 2020), i.e., a sharp increase a few hours before the main rain event, followed by a rapid decrease when the thunderstorm vanished. Accounting for such a peculiar trend in the PWV could be useful for setting up possible early warning systems for those areas prone to flash flooding, thus potentially providing a tool for disaster risk reduction

Monitoring of a geothermal reservoir by hybrid gravimetry; feasibility study applied to the Soultz-sous-Forêts and Rittershoffen sites in the Rhine graben

The study is devoted to the monitoring of a geothermal reservoir by hybrid gravimetry combining different types of instruments (permanent superconducting gravimeter, absolute ballistic gravimeter, and micro-gravimeters) and different techniques of measurements (both time-discrete and recording data collection). Using a micro-gravimetric repetition network around a reference station, which is regularly measured, leads to the knowledge of the time and space changes in surface gravity. Such changes can be linked to the natural or anthropic activities of the reservoir. A feasibility study using this methodology is applied to two geothermal sites in the Alsace region (France) of the Rhine graben. We show the results in terms of gravity double differences from weekly repetitions of a network of 11 stations around the geothermal reservoir of Soultz-sous-Forêts, separated into 5 loops during July–August 2013 and 2014 as well as preliminary results from 2 stations near Rittershoffen (ECOGI). We point out the importance of a precise leveling of the gravity points for the control of the vertical deformation. A first modeling of surface gravity changes induced by realistic geothermal density perturbations (Newtonian attraction) is computed in the frame of the existing geological model and leads to gravity changes below the μGal level being hence undetectable. However, and for the same case, borehole gravity modeling showed a significant anomaly with depth that can be used as a complementary monitoring method. We show that in the limit of our uncertainties (SD ~ 5 μGal), we do not detect any significant gravity change on the geothermal site of Soultz in agreement with the fact that there was indeed no geothermal activity during our analysis period. On the contrary, the measurements near Rittershoffen show a signal above the noise level which correlates in time with a production test but cannot be explained in terms of Newtonian attraction effects according to our basic numerical simulation

Strategies in the processing and analysis of continuous gravity record in active volcanic areas: the case of Mt. Vesuvius

This research is intended to describe new strategies in the processing and analysis of continuous gravity records collected in active volcanic areas and to assess how permanent gravity stations can improve the geophysical monitoring of a volcano. The experience of 15 years in continuous gravity monitoring on Mt. Vesuvius is discussed. Several geodynamic phenomena can produce temporal gravity changes. An eruption, for instance, is associated with the ascent of magma producing changes in the density distribution at depth, and leading to ground deformation and gravity changes The amplitude of such gravity variations is often quite small, in the order of 10-102 nms-2, so their detection requires high quality data and a rigorous procedure to isolate from the records those weak gravity signals coming from different sources. Ideally we need gravity signals free of all effects which are not of volcanic origin. Therefore solid Earth tide, ocean and atmospheric loading, instrumental drift or any kind of disturbances other than due to the volcano dynamics have to be removed. The state of the art on the modelling of the solid Earth tide is reviewed. The atmospheric dynamics is one of the main sources precluding the detection of small gravity signals. The most advanced methods to reduce the atmospheric effects on gravity are presented. As the variations of the calibration factors can prevent the repeatability of high-precision measurements, new approaches to model the instrumental response of mechanical gravimeters are proposed too. Moreover, a strategy for an accurate modelling of the instrumental drift and to distinguish it from longterm gravity changes is suggested

Study of high-pT charged particle suppression in PbPb compared to pp collisions at sqrt(sNN)=2.76 TeV.

The transverse momentum spectra of charged particles have been measured in pp and PbPb collisions at sqrt(sNN) = 2.76 TeV by the CMS experiment at the LHC. In the transverse momentum range pt = 5-10 GeV/c, the charged particle yield in the most central PbPb collisions is suppressed by up to a factor of 5 compared to the pp yield scaled by the number of incoherent nucleon-nucleon collisions. At higher pt, this suppression is significantly reduced, approaching roughly a factor of 2 for particles with pt in the range pt=40-100 GeV/c

Photogrammetric 3D model via smartphone GNSS sensor. Workflow, error estimate, and best practices

Geotagged smartphone photos can be employed to build digital terrain models using structure from motion-multiview stereo (SfM-MVS) photogrammetry. Accelerometer, magnetometer, and gyroscope sensors integrated within consumer-grade smartphones can be used to record the orientation of images, which can be combined with location information provided by inbuilt global navigation satellite system (GNSS) sensors to geo-register the SfM-MVS model. The accuracy of these sensors is, however, highly variable. In this work, we use a 200 m-wide natural rocky cliff as a test case to evaluate the impact of consumer-grade smartphone GNSS sensor accuracy on the registration of SfM-MVS models. We built a high-resolution 3D model of the cliff, using an unmanned aerial vehicle (UAV) for image acquisition and ground control points (GCPs) located using a differential GNSS survey for georeferencing. This 3D model provides the benchmark against which terrestrial SfM-MVS photogrammetry models, built using smartphone images and registered using built-in accelerometer/gyroscope and GNSS sensors, are compared. Results show that satisfactory post-processing registrations of the smartphone models can be attained, requiring: (1) wide acquisition areas (scaling with GNSS error) and (2) the progressive removal of misaligned images, via an iterative process of model building and error estimation

Gerstmann-Sträussler-Scheinker disease subtypes efficiently transmit in bank voles as genuine prion diseases.

Gerstmann-Sträussler-Scheinker disease (GSS) is an inherited neurodegenerative disorder associated with mutations in the prion protein gene and accumulation of misfolded PrP with protease-resistant fragments (PrPres) of 6–8 kDa

VEGF-induced intracellular Ca2+ oscillations are down-regulated and do not stimulate angiogenesis in breast cancer-derived endothelial colony forming cells.

Endothelial colony forming cells (ECFCs) represent a population of truly endothelial precursors that promote the angiogenic switch in solid tumors, such as breast cancer (BC). The intracellular Ca2+ toolkit, which drives the pro-angiogenic response to VEGF, is remodelled in tumor-associated ECFCs such that they are seemingly insensitive to this growth factor. This feature could underlie the relative failure of anti-VEGF therapies in cancer patients. Herein, we investigated whether and how VEGF uses Ca2+ signalling to control angiogenesis in BC-derived ECFCs (BCECFCs). Although VEGFR-2 was normally expressed, VEGF failed to induce proliferation and in vitro tubulogenesis in BC-ECFCs. Likewise, VEGF did not trigger robust Ca2+ oscillations in these cells. Similar to normal cells, VEGF-induced intracellular Ca2+ oscillations were triggered by inositol-1,4,5-trisphosphate-dependent Ca2+ release from the endoplasmic reticulum (ER) and maintained by store-operated Ca2+ entry (SOCE). However, InsP3-dependent Ca2+ release was significantly lower in BC-ECFCs due to the down-regulation of ER Ca2+ levels, while there was no remarkable difference in the amplitude, pharmacological profile and molecular composition of SOCE. Thus, the attenuation of the pro-angiogenic Ca2+ response to VEGF was seemingly due to the reduction in ER Ca2+ concentration, which prevents VEGF from triggering robust intracellular Ca2+ oscillations. However, the pharmacological inhibition of SOCE prevented BC-ECFC proliferation and in vitro tubulogenesis. These findings demonstrate for the first time that BC-ECFCs are insensitive to VEGF, which might explain at cellular and molecular levels the failure of anti-VEGF therapies in BC patients, and hint at SOCE as a novel molecular target for this disease

A New Genetic Risk Score to Predict the Outcome of Locally Advanced or Metastatic Breast Cancer Patients Treated With First-Line Exemestane: Results From a Prospective Study

Currently there are no reliable biomarkers to predict outcome of exemestane treatment. We designed a prospective study to investigate whether constitutive genetic background might affect response to therapy. In a population of 302 advanced breast cancer patients treated with exemestane we showed that a 5-polymorphism-based genetic score could be used to identify patients with different risks of progression and death.Introduction: Approximately 50% of locally advanced or metastatic breast cancer (MBC) patients treated with first-line exemestane do not show objective response and currently there are no reliable biomarkers to predict the outcome of patients using this therapy. The constitutive genetic background might be responsible for differences in the outcome of exemestane-treated patients. We designed a prospective study to investigate the role of germ line polymorphisms as biomarkers of survival. Patients and Methods: Three hundred two locally advanced or MBC patients treated with first-line exemestane were genotyped for 74 germ line polymorphisms in 39 candidate genes involved in drug activity, hormone balance, DNA replication and repair, and cell signaling pathways. Associations with progression-free survival (PFS) and overall survival (OS) were tested with multivariate Cox regression. Bootstrap resampling was used as an internal assessment of results reproducibility. Results: Cytochrome P450 19A1-rs10046TC/CC, solute carrier organic anion transporter 1B1-rs4149056TT, adenosine triphosphate binding cassette subfamily G member 2-rs2046134GG, fibroblast growth factor receptor-4-rs351855TT, and X-ray repair cross complementing 3-rs861539TT were significantly associated with PFS and then combined into a risk score (0-1, 2, 3, or 4-6 risk points). Patients with the highest risk score (4-6 risk points) compared with ones with the lowest score (0-1 risk points) had a median PFS of 10 months versus 26.3 months (adjusted hazard ratio [AdjHR], 3.12 [95% confidence interval (CI), 2.18-4.48]; P < .001) and a median OS of 38.9 months versus 63.0 months (AdjHR, 2.41 [95% CI, 1.22-4.79], P = .012), respectively. Conclusion: In this study we defined a score including 5 polymorphisms to stratify patients for PFS and OS. This score, if validated, might be translated to personalize locally advanced or MBC patient treatment and management

Serum Albumin Is Inversely Associated With Portal Vein Thrombosis in Cirrhosis

We analyzed whether serum albumin is independently associated with portal vein thrombosis (PVT) in liver cirrhosis (LC) and if a biologic plausibility exists. This study was divided into three parts. In part 1 (retrospective analysis), 753 consecutive patients with LC with ultrasound-detected PVT were retrospectively analyzed. In part 2, 112 patients with LC and 56 matched controls were entered in the cross-sectional study. In part 3, 5 patients with cirrhosis were entered in the in vivo study and 4 healthy subjects (HSs) were entered in the in vitro study to explore if albumin may affect platelet activation by modulating oxidative stress. In the 753 patients with LC, the prevalence of PVT was 16.7%; logistic analysis showed that only age (odds ratio [OR], 1.024; P = 0.012) and serum albumin (OR, -0.422; P = 0.0001) significantly predicted patients with PVT. Analyzing the 112 patients with LC and controls, soluble clusters of differentiation (CD)40-ligand (P = 0.0238), soluble Nox2-derived peptide (sNox2-dp; P &lt; 0.0001), and urinary excretion of isoprostanes (P = 0.0078) were higher in patients with LC. In LC, albumin was correlated with sCD4OL (Spearman's rank correlation coefficient [r(s)], -0.33; P &lt; 0.001), sNox2-dp (r(s), -0.57; P &lt; 0.0001), and urinary excretion of isoprostanes (r(s), -0.48; P &lt; 0.0001) levels. The in vivo study showed a progressive decrease in platelet aggregation, sNox2-dp, and urinary 8-iso prostaglandin F2 alpha-III formation 2 hours and 3 days after albumin infusion. Finally, platelet aggregation, sNox2-dp, and isoprostane formation significantly decreased in platelets from HSs incubated with scalar concentrations of albumin. Conclusion: Low serum albumin in LC is associated with PVT, suggesting that albumin could be a modulator of the hemostatic system through interference with mechanisms regulating platelet activation

Towards a muon collider

A muon collider would enable the big jump ahead in energy reach that is needed for a fruitful exploration of fundamental interactions. The challenges of producing muon collisions at high luminosity and 10 TeV centre of mass energy are being investigated by the recently-formed International Muon Collider Collaboration. This Review summarises the status and the recent advances on muon colliders design, physics and detector studies. The aim is to provide a global perspective of the field and to outline directions for future work